IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation
Identifieur interne : 000961 ( Main/Exploration ); précédent : 000960; suivant : 000962IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation
Auteurs : Suzanne M. Hurst [Royaume-Uni] ; Thomas S. Wilkinson [Royaume-Uni] ; Rachel M. Mcloughlin [Royaume-Uni] ; Suzanne Jones [Royaume-Uni] ; Sankichi Horiuchi [Japon] ; Naoki Yamamoto [Japon] ; Stefan Rose-John [Allemagne] ; Gerald M. Fuller [États-Unis] ; Nicholas Topley [Royaume-Uni] ; Simon A. Jones [Royaume-Uni]Source :
- Immunity [ 1074-7613 ] ; 2000.
Abstract
During acute inflammation, leukocyte recruitment is characterized by an initial infiltration of neutrophils, which are later replaced by a more sustained population of mononuclear cells. Based on both clinical and experimental evidence, we present a role for IL-6 and its soluble receptor (sIL-6R) in controlling this pattern of leukocyte recruitment during peritoneal inflammation. Liberation of sIL-6R from the initial neutrophil infiltrate acts as a regulator of CXC and CC chemokine expression, which contributes to a suppression of neutrophil recruitment and the concurrent attraction of mononuclear leukocytes. Soluble IL-6R-mediated signaling is therefore an important intermediary in the resolution of inflammation and supports transition between the early predominantly neutrophilic stage of an infection and the more sustained mononuclear cell influx.
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DOI: 10.1016/S1074-7613(01)00151-0
Affiliations:
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Based on both clinical and experimental evidence, we present a role for IL-6 and its soluble receptor (sIL-6R) in controlling this pattern of leukocyte recruitment during peritoneal inflammation. Liberation of sIL-6R from the initial neutrophil infiltrate acts as a regulator of CXC and CC chemokine expression, which contributes to a suppression of neutrophil recruitment and the concurrent attraction of mononuclear leukocytes. Soluble IL-6R-mediated signaling is therefore an important intermediary in the resolution of inflammation and supports transition between the early predominantly neutrophilic stage of an infection and the more sustained mononuclear cell influx.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Japon</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Alabama</li><li>Région de Kantō</li><li>Schleswig-Holstein</li></region><settlement><li>Kiel</li><li>Tokyo</li></settlement></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Hurst, Suzanne M" sort="Hurst, Suzanne M" uniqKey="Hurst S" first="Suzanne M" last="Hurst">Suzanne M. Hurst</name></noRegion><name sortKey="Jones, Simon A" sort="Jones, Simon A" uniqKey="Jones S" first="Simon A" last="Jones">Simon A. Jones</name><name sortKey="Jones, Simon A" sort="Jones, Simon A" uniqKey="Jones S" first="Simon A" last="Jones">Simon A. Jones</name><name sortKey="Jones, Suzanne" sort="Jones, Suzanne" uniqKey="Jones S" first="Suzanne" last="Jones">Suzanne Jones</name><name sortKey="Mcloughlin, Rachel M" sort="Mcloughlin, Rachel M" uniqKey="Mcloughlin R" first="Rachel M" last="Mcloughlin">Rachel M. Mcloughlin</name><name sortKey="Topley, Nicholas" sort="Topley, Nicholas" uniqKey="Topley N" first="Nicholas" last="Topley">Nicholas Topley</name><name sortKey="Wilkinson, Thomas S" sort="Wilkinson, Thomas S" uniqKey="Wilkinson T" first="Thomas S" last="Wilkinson">Thomas S. Wilkinson</name></country><country name="Japon"><region name="Région de Kantō"><name sortKey="Horiuchi, Sankichi" sort="Horiuchi, Sankichi" uniqKey="Horiuchi S" first="Sankichi" last="Horiuchi">Sankichi Horiuchi</name></region><name sortKey="Yamamoto, Naoki" sort="Yamamoto, Naoki" uniqKey="Yamamoto N" first="Naoki" last="Yamamoto">Naoki Yamamoto</name></country><country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Rose John, Stefan" sort="Rose John, Stefan" uniqKey="Rose John S" first="Stefan" last="Rose-John">Stefan Rose-John</name></region></country><country name="États-Unis"><region name="Alabama"><name sortKey="Fuller, Gerald M" sort="Fuller, Gerald M" uniqKey="Fuller G" first="Gerald M" last="Fuller">Gerald M. Fuller</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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